Special Chemicals

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Item Code: PC141

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• Saturated solutions of potassium iodide can be an emergency treatment for hyperthyroidism (so-called thyroid storm), as high amounts of iodide temporarily suppress secretion of thyroxine from the thyroid gland.^[10] The dose typically begins with a loading dose, then 1/3 mL SSKI (5 drops or 250 mg iodine as iodide), three times per day.
• Iodide solutions made from a few drops of SSKI added to drinks have also been used as expectorants to increase the water content of respiratory secretions and encourage effective coughing.^[11]
• SSKI has been proposed as a topical treatment for sporotrichosis, but no trials have been conducted to determine the efficacy or side effects of such treatment.^[12]
• Potassium iodide has been used for symptomatic treatment of erythema nodosum patients for persistent lesions whose cause remains unknown. It has been used in cases of erythema nodosum associated with Crohn's disease.^[13]
• Due to its high potassium content, SSKI is extremely bitter, and if possible it is administered in a sugar cube or small ball of bread. It may also be mixed into much larger volumes of juices.
• Neither SSKI or KI tablets are used as nutritional supplements, since the nutritional requirement for iodine is only 150 micrograms or 0.15 mg of iodide per day. Thus, a drop of SSKI provides 50/0.15 = 333 times the daily iodine requirement, and a standard KI tablet provides twice this much..

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Citronellal is a major isolate in distilled oils from the plants Cymbopogon,^[2] lemon-scented gum, and lemon-scented teatree. The (-)-(S)-enantiomer of citronellal makes up up to 80% of the leaf oil from kaffir lime leaves and is the compound responsible for its characteristic aroma.

Citronellal has insect repellent properties, and research shows high repellent effectiveness against mosquitoes.^[3] Research shows that citronellal has strong antifungal qualities..

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Adenine /dnn/ (A, Ade) is a nucleobase (a purine derivative). Its derivatives have a variety of roles in biochemistry including cellular respiration, in the form of both the energy-rich adenosine triphosphate (ATP) and the cofactors nicotinamide adenine dinucleotide (NAD) and flavin adenine dinucleotide (FAD). It also has functions in protein synthesis and as a chemical component of DNA and RNA.^[2] The shape of adenine is complementary to either thymine in DNA or uracil in RNA.

The image on the right shows pure adenine, as an independent molecule. When connected into DNA, a covalent bond is formed between deoxyribose sugar and the bottom left nitrogen, so removing the hydrogen. The remaining structure is called an adenine residue, as part of a larger molecule. Adenosine is adenine reacted with ribose as used in RNA and ATP; deoxyadenosine, adenine attached to deoxyribose, as is used to form DNA.Adenine forms several tautomers, compounds that can be rapidly interconverted and are often considered equivalent. However, in isolated conditions, i.e. in an inert gas matrix and in the gas phase, mainly the 9H-adenine tautomer is found

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Item Code: PCCHEM-005

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Galactitol is produced from galactose in a reaction catalyzed by aldose reductase. Galactose itself comes from the metabolism of the disaccharide lactose into glucose and galactose.

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Item Code: 0104

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• Taurine is used in the preparation of the anthelmintic drug netobimin (Totabin).
• Taurolidine
• Taurocholic acid & Tauroselcholic acid.
• Tauromustine
• Taurine

or2-aminoethanesulfonic acid, is anorganic compoundthat is widely distributed in animal tissues.^[1]It is a major constituent ofbileand can be found in thelarge intestine, and accounts for up to 0.1% of total human body weight. Taurine has many fundamental biological roles, such as conjugation ofbile acids,antioxidation,osmoregulation,membrane stabilization, and modulation ofcalcium signaling. It is essential forcardiovascularfunction, and development and function ofskeletal muscle, theretina, and thecentral nervous system. Taurine is unusual among biological molecules in being asulfonic acid, while the vast majority of biologically occurring acids contain the more weakly acidiccarboxyl group. While taurine is sometimes called an amino acid, and indeed is anacidcontaining anaminogroup, it is not anamino acidin the usual biochemical meaning of the term, which refers to compounds containing both anaminoand acarboxylgroup.

Taurine is named after theLatintaurus(acognateof theGreek) which meansbullorox, as it was first isolated from ox bile in 1827 by German scientistsFriedrich TiedemannandLeopold Gmelin.Taurine is involved in a number of crucial physiological processes. However, its role in these processes is not clearly understood and the influence of high taurine doses on these processes is uncertain. A substantial increase in the plasma concentration of growth hormone was reported in some epileptic patients during taurine tolerance testing (oral dose of 50 mg per kg body mass per day), suggesting a potential to stimulate the hypothalamus and to modify neuroendocrine function.^[60] A 1966 study found an indication that taurine (2 g/day) has some function in the maintenance and possibly in the induction of psoriasis.

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Azide inhibits cytochrome oxidase by binding irreversibly to the heme cofactor in a process similar to the action of carbon monoxide. Sodium azide particularly affects organs that undergo high rates of respiration, such as the heart and the brain.

It produces extrapyramidal symptoms with necrosis of the cerebral cortex, cerebellum, and basal ganglia. Toxicity may also include hypotension, blindness and hepaticnecrosis. Sodium azide increases cyclic GMP levels in brain and liver by activation of guanylate cyclase..

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Item Code: PB121

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Methyl 4-(aminomethyl)benzoate hydrochloride may be used in the preparation of methyl 4-((3-butyl-3-phenylureido)methyl)benzoate.

Methyl 4-(aminomethyl)benzoate hydrochloride is an amino acid ester hydrochloride. Its synthesis by esterification reaction has been reported. It plays a role during the preparation of a novel hepatitis C virus (HCV) helicase inhibitor.

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